MM 102

Cat. No. 5307

MM 102 C35H49F2N7O4.CF3CO2H

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Chemical Name: 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate

Biological Activity

Potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

Technical Data

M.Wt:
783.83
Formula:
C35H49F2N7O4.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Karatas et al (2013) High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc. 135 669. PMID: 23210835.

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Keywords: MM 102, supplier, MM102, Mixed, lineage, leukemia, 1, MLL1, WD, repeat-containing, protein, 5, WDR5, interaction, inhibitors, inhibits, leukemia, leukaemia, 14173292483, 1417329_24_83, Tocris Bioscience, Lysine Methyltransferase products

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