Cat. No. 5304
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-
Biological ActivityHigh affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387. PMID: 25119038.
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690. PMID: 19054769.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841. PMID: 8807817.
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Keywords: FICZ, supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Tocris Bioscience, Aryl Hydrocarbon Receptor Agonist products
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