Cat. No. 5304

FICZ C19H12N2O [172922-91-7]

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Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

Biological Activity

High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data

Soluble to 25 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387. PMID: 25119038.

Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690. PMID: 19054769.

Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841. PMID: 8807817.

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Keywords: FICZ, supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Tocris Bioscience, Aryl Hydrocarbon Receptor Agonist products

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