Cat. No. 5304
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-
Biological ActivityHigh affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387. PMID: 25119038.
Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690. PMID: 19054769.
Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841. PMID: 8807817.
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Keywords: FICZ, supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Tocris Bioscience, Aryl Hydrocarbon Receptor Agonist products
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