FICZ

Cat. No. 5304

FICZ C19H12N2O [172922-91-7]

Price and Availability

For FICZ pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

Biological Activity

High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data

M.Wt:
284.31
Formula:
C19H12N2O
Solubility:
Soluble to 25 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
172922-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Moura-Alves et al (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512 387. PMID: 25119038.

Wincent et al (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284 2690. PMID: 19054769.

Rannug et al (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2 841. PMID: 8807817.

If you know of a relevant reference for FICZ please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses FICZ from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: FICZ, supplier, High, affinity, aryl, hydrogen, receptors, AhR, agonists, agonism, Tocris Bioscience, Aryl Hydrocarbon Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

New Products in this Area

Megestrol Acetate

Synthetic progesterone analog

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

(S)-Equol

Potent estrogen receptor β (ERβ) agonist

Ailanthone

Potent inhibitor of androgen receptor (AR)

(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

AGN 193109

High affinity pan-RAR antagonist

SR 9243

Selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.