Cat. No. 5301

BPTES C24H24N6O2S3 [314045-39-1]

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Chemical Name: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

Biological Activity

Allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

Technical Data

Soluble to 20 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Le et al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 15 110. PMID: 22225880.

Shukla et al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 55 10551. PMID: 23151085.

DeLaBarre et al (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764. PMID: 22049910.

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Keywords: BPTES, supplier, allosteric, glutaminases, gls1, inhibitors, inhibits, selective, Tocris Bioscience, Glutaminase Inhibitor products

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