BI 605906

Cat. No. 5300new

BI 605906 C17H22F2N4O3S2 [960293-88-3]

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Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide

Biological Activity

Selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

Technical Data

M.Wt:
432.51
Formula:
C17H22F2N4O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
960293-88-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK▀ for activation by autophosphorylation. Biochem.J. 461 531. PMID: 24911653.

Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93. PMID: 21138416.

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Citations are publications that use Tocris products.

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Keywords: BI 605906, supplier, BI605906, ikk-2, NF-kappaB, NF-kB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, ab, kinases, NF-κβ, Tocris Bioscience, IκB Kinase Inhibitor products

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