Cat. No. 5296
Alternative Name: [Pen5,DTrp7,Orn8]hU-II(4-11)
Biological ActivitySelective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965. PMID: 24992374.
Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155. PMID: 14645137.
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Keywords: Urantide, supplier, Selective, competitive, urotensin, II, antagonists, Tocris Bioscience, Urotensin-II Receptor Antagonist products
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