Urantide

Cat. No. 5296

Urantide Asp-Pen-Phe-D-Trp-Orn-Tyr-Cys-Val

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Alternative Name: [Pen5,DTrp7,Orn8]hU-II(4-11)

Biological Activity

Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

Technical Data

M.Wt:
1075.26
Formula:
C51H66N10O12S2
Sequence:
DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
669089-53-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965. PMID: 24992374.

Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155. PMID: 14645137.

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Keywords: Urantide, supplier, Selective, competitive, urotensin, II, antagonists, Tocris Bioscience, Urotensin-II Receptor Antagonist products

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