Oltipraz

Cat. No. 5294

Oltipraz C8H6N2S3 [64224-21-1]

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Chemical Name: 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

Biological Activity

Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Technical Data

M.Wt:
226.34
Formula:
C8H6N2S3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
64224-21-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Merrell et al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128. PMID: 18418891.

Maher et al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597. PMID: 17668877.

Manandhar et al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17. PMID: 17854798.

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Keywords: Oltipraz, supplier, Nrf2, activators, nuclear, factor-E2-related, factor-2, phase-I, -II, drug-metabolizing, enzymes, transporters, chemopreventive, Tocris Bioscience, Nrf2 Activator products

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