Cat. No. 5292
Alternative Name: 2-Chloro-2'-deoxyadenosine
Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin
Biological ActivityAdenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Robak et al (2006) Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23. PMID: 18221024.
Bryson et al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872. PMID: 7507037.
Seto et al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377. PMID: 2579098.
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Citations are publications that use Tocris products. Selected citations for Cladribine include:
Weiterer et al (2015) Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. J Biomed Sci 10 e0143163. PMID: 26571499.
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Keywords: Cladribine, supplier, leukemia, adenosine, deaminase, antileukemic, proapoptotic, ribonuclease, reductase, deoxyadenosine, analogue, analog, 2-Chloro-2-deoxyadenosine, antimetabolites, Tocris Bioscience, Apoptosis Inducing products