Cat. No. 5292

Cladribine C10H12ClN5O3 [4291-63-8]

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Alternative Name: 2-Chloro-2'-deoxyadenosine

Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol

Biological Activity

Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Robak et al (2006) Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23. PMID: 18221024.

Bryson et al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872. PMID: 7507037.

Seto et al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377. PMID: 2579098.

If you know of a relevant reference for Cladribine please let us know.

Citations are publications that use Tocris products. Selected citations for Cladribine include:

Weiterer et al (2015) Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. J Biomed Sci 10 e0143163. PMID: 26571499.

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Keywords: Cladribine, supplier, leukemia, adenosine, deaminase, antileukemic, proapoptotic, ribonuclease, reductase, deoxyadenosine, analogue, analog, 2-Chloro-2-deoxyadenosine, antimetabolites, Tocris Bioscience, Apoptosis Inducing products

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