Cat. No. 5287
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)
Biological ActivityKDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975. PMID: 24971742.
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Keywords: NSC 636819, supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Tocris Bioscience, Histone Demethylase Inhibitor products
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