Cat. No. 5287
Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)
Biological ActivityKDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975. PMID: 24971742.
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Keywords: NSC 636819, supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Tocris Bioscience, Histone Demethylase Inhibitor products