NSC 636819

Cat. No. 5287

NSC 636819 C22H12Cl4N2O4 [1618672-71-1]

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Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene

Biological Activity

KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data

Soluble to 10 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975. PMID: 24971742.

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Keywords: NSC 636819, supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Tocris Bioscience, Histone Demethylase Inhibitor products

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