Cat. No. 5286
Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-
Biological ActivityPotent and selective inhibitor of Aurora kinase A (IC50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yuan et al (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinse in the KCL-22 cell model. Carcinogenesis 33 285. PMID: 22116466.
Aliagas-Martin et al (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem. 52 3300. PMID: 19402633.
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Keywords: TC-S 7010, supplier, TC-S7010, Aurora, kinase, A, potent, selective, inhibitors, inhibits, antiproliferative, Tocris Bioscience, Aurora Kinase Inhibitor products
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