ZLN 024 hydrochloride

Cat. No. 5285

ZLN 024 hydrochloride C13H13BrN2OS.HCl

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Chemical Name: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride

Biological Activity

Allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

Technical Data

M.Wt:
361.69
Formula:
C13H13BrN2OS.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Li et al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325. PMID: 24055643.

Zhang et al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092. PMID: 23977216.

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Keywords: ZLN 024 hydrochloride, supplier, ZLN024, hydrochloride, allosteric, AMPK, activator, diabetes, mellitus, and, metabolic, syndrome, AMP, activated, protein, kinase, glucose, tolerance, Tocris Bioscience, AMPK Activator products

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