SAG 21k

Cat. No. 5282

SAG 21k C29H28ClF2N3O2S [946002-48-8]

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Chemical Name: 3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide

Biological Activity

Potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Brunton et al (2009) Potent agonists of the Hedgehog signaling pathway. Bioorg.Med.Chem.Lett. 19 4308. PMID: 19500978.

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Keywords: SAG 21k, supplier, SAG21k, Hedgehog, Hh, signaling, activators, activation, orally, bioavailable, brain, penetrant, potent, Tocris Bioscience, Hedgehog Signaling Activator products

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