AC 5216

Cat. No. 5281

AC 5216 C23H23N5O2 [226954-04-7]

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Alternative Name: XBD173

Chemical Name: N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide

Biological Activity

Ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.

Technical Data

M.Wt:
401.46
Formula:
C23H23N5O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with sonication
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
226954-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Qiu et al (2013) Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45 40. PMID: 23624119.

Kita et al (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 142 1059. PMID: 15249420.

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Citations are publications that use Tocris products.

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Keywords: AC 5216, supplier, AC5216, anxiolytic, anti-anxiety, antidepressant, mitochondrial, benzodiazepine, BZD, ligands, PBR, TSPO, GABAA, Tocris Bioscience, Translocator Protein Ligand products

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