Cat. No. 5279
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3
Biological ActivityPotent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Dodge et al (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 287 23246. PMID: 22593577.
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Keywords: IWP 12, supplier, IWP12, potent, porcupine, porcn, wnt, bcatenin, beta_catenin, βcatenin, MBOAT, membrane-bound, O-acyltransferases, Tocris Bioscience, PORCN Inhibitor products
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