Cat. No. 5276
Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazol
Biological ActivitySelective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520. PMID: 24951278.
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Keywords: NS 19504, supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products
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