Cat. No. 5276
Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazol
Biological ActivitySelective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520. PMID: 24951278.
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Keywords: NS 19504, supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products
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