NS 19504

Cat. No. 5276

NS 19504 C10H9BrN2S [327062-46-4]

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Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazolamine

Biological Activity

Selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520. PMID: 24951278.

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Keywords: NS 19504, supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products

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