Cat. No. 5276
Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazol
Biological ActivitySelective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520. PMID: 24951278.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NS 19504 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NS 19504, supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products
Find multiple products by catalog number
New Products in this Area
Potent and selective KV11.1 (hERG) channel blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.