Cat. No. 5273
Chemical Name: (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-
Biological ActivityPotent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg.Med.Chem. 20 4348. PMID: 22705020.
Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764. PMID: 17656313.
Kinder et al (2001) Synthesis and antitumor activity of ester-modified analogues of bengamide B. J.Med.Chem. 44 3692. PMID: 11606134.
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Keywords: Bengamide B, supplier, Methionyl, aminopeptidase, MetAP1, MetAP2, potent, NF-κB, inhibitors, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, inhibits, Tocris Bioscience, NF-κB and IκB Inhibitor products
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