Cat. No. 5271
Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(ph
Biological ActivityPotent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836. PMID: 24853942.
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Keywords: UNC 3230, supplier, UNC3230, potent, selective, PIP5K1C, inhibitors, inhibits, antinociceptive, reduces, nociception, chronic, pain, phosphatidylinositol-4-phosphate, 5-kinase, type, I, gamma, Tocris Bioscience, Other Kinase Inhibitor products
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