Toyocamycin

Cat. No. 5270

Toyocamycin C12H13N5O4 [606-58-6]

Price and Availability

For Toyocamycin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Biological Activity

Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.

Technical Data

M.Wt:
291.26
Formula:
C12H13N5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
606-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79. PMID: 22852048.

Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797. PMID: 16556935.

Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586. PMID: 2177464.

If you know of a relevant reference for Toyocamycin please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Toyocamycin from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Toyocamycin, supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Tocris Bioscience, Antibiotic products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

NITD 008

Antiviral; selective flavivirus inhibitor

Nanchangmycin

Antiviral; active against Zika, West Nile and dengue viruses

25-Hydroxycholesterol

Antiviral; also α-crystallin (cryAB) chaperone

Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.