Cat. No. 5270
Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrro
Biological ActivityAdenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79. PMID: 22852048.
Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797. PMID: 16556935.
Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586. PMID: 2177464.
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Keywords: Toyocamycin, supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Tocris Bioscience, Antibiotic products
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