Cat. No. 5269
Alternative Name: T56-LIMKi
Chemical Name: 3-Methyl-N-[3-[[[3-(trifluoromethyl
Biological ActivitySelective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rak et al (2014) Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 1 39. PMID: 25593987.
Mashiach-Farkash et al (2012) Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 3 629. PMID: 22776759.
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Keywords: T 5601640, supplier, T5601640, Selective, LIMK2, inhibitors, inhibits, lim, kinases, antitumour, antitumor, cofilin, Tocris Bioscience, LIMK Inhibitor products
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