Bazedoxifene acetate

Cat. No. 5263

Bazedoxifene acetate C30H34N2O3.C2H4O2 [198481-33-3]

Price and Availability

For Bazedoxifene acetate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate

Biological Activity

Potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
530.65
Formula:
C30H34N2O3.C2H4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
198481-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999. PMID: 15961563.

If you know of a relevant reference for Bazedoxifene acetate please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Bazedoxifene acetate from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Bazedoxifene acetate, supplier, selective, estrogen, receptors, modulator, SERM, selective, for, ERα, Tocris Bioscience, Estrogen and Related Receptor Modulator products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Estrogen Pathway

Estrogen Signaling Pathway

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. View pathway or download PDF today.

divider line

New Products in this Area

Megestrol Acetate

Synthetic progesterone analog

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

(S)-Equol

Potent estrogen receptor β (ERβ) agonist

Ailanthone

Potent inhibitor of androgen receptor (AR)

(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

AGN 193109

High affinity pan-RAR antagonist

SR 9243

Selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.