Cat. No. 5263
Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)
Biological ActivityPotent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999. PMID: 15961563.
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Keywords: Bazedoxifene acetate, supplier, selective, estrogen, receptors, modulator, SERM, selective, for, ERα, Tocris Bioscience, Estrogen and Related Receptor Modulator products
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