WWL 113

Cat. No. 5259

WWL 113 C29H26N2O4 [947669-86-5]

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Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester

Biological Activity

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data

M.Wt:
466.53
Formula:
C29H26N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
947669-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113. PMID: 24362705.

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Citations are publications that use Tocris products.

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Keywords: WWL 113, supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

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