Cat. No. 5256
Chemical Name: 4-Methyl-N-9H-xanthen-9-yl-benzenes
Biological ActivitySelective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100. PMID: 24881566.
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Keywords: AH 7614, supplier, AH7614, selective, free, fatty, acid, 4, FFA4, receptor, antagonist, GPR120, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
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