Cat. No. 5251
Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrr
Biological ActivityIAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J.Pharmacol.Exp.Ther. 349 319. PMID: 24623800.
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Keywords: UC 112, supplier, UC112, inhibitors, inhibits, apoptosis, proteins, antitumor, multidrug, resistant, caspase, apoptosis, Tocris Bioscience, Inhibitor of Apoptosis Inhibitor products