Cat. No. 5250

Ramipril C23H32N2O5 [87333-19-5]

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Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Biological Activity

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKß/AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5. PMID: 24741076.

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1. PMID: 16398929.

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493. PMID: 2905962.

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Keywords: Ramipril, supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Tocris Bioscience, Angiotensin-Converting Enzyme Inhibitor products

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