Cat. No. 5250
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Et
Biological ActivityNon-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKß/AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5. PMID: 24741076.
Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1. PMID: 16398929.
Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493. PMID: 2905962.
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Citations are publications that use Tocris products.
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Keywords: Ramipril, supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Tocris Bioscience, Angiotensin-Converting Enzyme Inhibitor products
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