Cat. No. 5248
Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-be
Biological ActivityPotent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089.
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Keywords: XAP 044, supplier, XAP044, potent, specific, mGlu7, antagonists, glutamate, metabotropic, group, III, receptors, venus, flytrap, domain, VFTD, anti-anxiety, Brain, penetrant, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products
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