Cat. No. 5248
Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-be
Biological ActivityPotent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses XAP 044 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: XAP 044, supplier, XAP044, potent, specific, mGlu7, antagonists, glutamate, metabotropic, group, III, receptors, venus, flytrap, domain, VFTD, anti-anxiety, Brain, penetrant, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective mGlu2 receptor positive allosteric modulator(±)-ADX 71743
Negative allosteric modulator at mGlu7; brain penetrant
March 18 - 22, 2017
Little Rock, ARK, USA