NVP ADW 742
Cat. No. 5247
Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[tran
Biological ActivityATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhou et al (2011) The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25 1565. PMID: 21455580.
Warshamana-Greene et al (2005) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 11 1563. PMID: 15746061 .
Warshamana-Greene et al (2004) The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 3 527. PMID: 15141010.
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Keywords: NVP ADW 742, supplier, NVPADW742, ATP, competitive, inhibitors, inhibits, of, IGF1, receptors, kinases, c-Kit, small, cell, lung, cancer, cell, lines, SCLC, insulin-like, growth, factor-1, receptor, Tocris Bioscience, Insulin and Insulin-like Receptor Inhibitor products
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