NVP ADW 742

Cat. No. 5247

NVP ADW 742 C28H31N5O [475488-23-4]

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Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Biological Activity

ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).

Technical Data

M.Wt:
453.58
Formula:
C28H31N5O
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
475488-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zhou et al (2011) The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25 1565. PMID: 21455580.

Warshamana-Greene et al (2005) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 11 1563. PMID: 15746061 .

Warshamana-Greene et al (2004) The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 3 527. PMID: 15141010.

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Keywords: NVP ADW 742, supplier, NVPADW742, ATP, competitive, inhibitors, inhibits, of, IGF1, receptors, kinases, c-Kit, small, cell, lung, cancer, cell, lines, SCLC, insulin-like, growth, factor-1, receptor, Tocris Bioscience, Insulin and Insulin-like Receptor Inhibitor products

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