Ebselen

Cat. No. 5245

Ebselen C13H9NOSe [60940-34-3]

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Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one

Biological Activity

Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory.

Technical Data

M.Wt:
274.18
Formula:
C13H9NOSe
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
60940-34-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989. PMID: 16309189.

Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237. PMID: 11133813.

Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153. PMID: 7590103.

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Keywords: Ebselen, supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, Tocris Bioscience, Antioxidant products

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