Cat. No. 5243
Chemical Name: N-(3-Chloro-5-fluorophenyl)-4-nitro
Biological ActivityHigh affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Rogers et al (2013) Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 56 1739. PMID: 23363003.
Scheuermann et al (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 9 271. PMID: 23434853.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-S 7009 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-S 7009, supplier, TC-S7009, high, affinity, inhibits, inhibitors, HIF2α, HIF2a, HIF2alpha, PASB, hypoxia-inducible, factors, Tocris Bioscience, Hypoxia Inducible Factor Inhibitor products
Find multiple products by catalog number
New Products in this Area
Gene switch ligand for use in induceable gene expression systemsML 334
Inhibitor of Keap1- Nrf2 interactionRA 839
Nrf2 activator; inhibits Nrf2/Keap1 interactionGN 44028
Potent HIF-1α inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.