Cat. No. 5242
Chemical Name: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)m
Biological ActivitySelective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524. PMID: 24097188.
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Keywords: CLP 257, supplier, CLP257, Selective, KCC2, K+-Cl-, cotransporters, activators, neuropathic, pain, Tocris Bioscience, K+/Cl-Cotransporter 2 Activator products