Cat. No. 5237
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R
Biological ActivityProtein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kedei et al (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol. 85 313. PMID: 23146662.
Jalava et al (1990) Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Cancer Res. 50 3422. PMID: 2334938.
Dale et al (1989) Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res. 49 3242. PMID: 2720677.
Dell'Aquila et al (1988) Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res. 48 3702. PMID: 3132318.
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Keywords: Bryostatin 2, supplier, Protein, Kinase, C, PKC, activators, analogue, Bryostatin, 1, antitumor, macrocyclic, lactone, arachidonic, acid, release, Tocris Bioscience, Protein Kinase C Activator products
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