Cat. No. 5233
Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-meth
Biological ActivityRho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
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Certificate of Analysis / Safety Data Sheet
Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877. PMID: 20171952.
Evelyn et al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249. PMID: 17699722.
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Keywords: CCG 1423, supplier, CCG1423, Rho, SRF, pathway, inhibitors, inhibits, intermediate, mesoderm, differentiation, ESC, embryonic, stem, cells, serum, response, factors, cancer, Tocris Bioscience, Stem Cell Differentiation products
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