AZ 191

Cat. No. 5232

AZ 191 C24H27N7O [1594092-37-1]

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Chemical Name: N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine

Biological Activity

Potent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ 191 is reviewed on the chemical probes website.

Technical Data

M.Wt:
429.52
Formula:
C24H27N7O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1594092-37-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ashford et al (2014) A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3 to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem.J. 457 43. PMID: 24134204.

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Keywords: AZ 191, supplier, AZ191, potent, dyrk1b, dual, specificity, tyrosine, phosphorylation, regulated, kinases, inhibitors, inhibits, selective, Tocris Bioscience, DYRK Inhibitor products

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