Cat. No. 5229
Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]
Biological ActivityHigh affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903. PMID: 17110115.
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Keywords: ABP 688, supplier, ABP688, metabotropic, glutamate, receptors, group, I, human, mGlu5, mGluR5, antagonists, antagonism, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products