ABP 688

Cat. No. 5229

ABP 688 C15H16N2O [924298-51-1]

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Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime

Biological Activity

High affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903. PMID: 17110115.

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Keywords: ABP 688, supplier, ABP688, metabotropic, glutamate, receptors, group, I, human, mGlu5, mGluR5, antagonists, antagonism, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products

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