NSC 95397

Cat. No. 1547

NSC 95397 C14H14O4S2 [93718-83-3]

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Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone

Biological Activity

Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.

Technical Data

M.Wt:
310.38
Formula:
C14H14O4S2
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at -20°C
CAS No:
93718-83-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016. PMID: 15652497.

Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64. PMID: 14718602.

Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720. PMID: 11901209.

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Keywords: NSC 95397, supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, inhibits, NSC95397, Tocris Bioscience, Cdc25 Phosphatase Inhibitor products

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