Cat. No. 5214
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3
Biological ActivityPotent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Narytnyk et al (2014) Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons. Stem Cell Rev. 10 316. PMID: 24399192.
Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U.S.A. 109 E1848-57. PMID: 22645348.
Chen et al (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol. 5 100. PMID: 19125156.
If you know of a relevant reference for IWP 4 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses IWP 4 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: IWP 4, supplier, IWP4, potent, inhibitors, inhibits, Wnt, beta-catenin, β-catenin, b-catenin, cardiomyocytes, ESCs, iPSCs, stem, cells, embryonic, pluripotent, differentiation, Tocris Bioscience, β-catenin products
Find multiple products by catalog number
New Products in this Area
Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.