LL 37

Cat. No. 5213

LL 37 Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

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Biological Activity

Antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. Also triggers apoptosis in colon cancer cells. Cell permeable.

Technical Data

M.Wt:
4493.32
Formula:
C205H340N60O53
Sequence:
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
154947-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Steinstraesser et al (2014) Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. Mol.Ther. 22 734. PMID: 24394186.

Ren et al (2012) Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 72 6512. PMID: 23100468.

Seil et al (2010) Spotlight on human LL-37, an immunomodulatory peptide with promising cell-penetrating properties. Pharmaceuticals 3 3435.

Yang et al (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J.Exp.Med. 192 1069. PMID: 11015447.

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Keywords: LL 37, supplier, LL37, antimicrobial, derivative, cathelicidin, chemotaxis, chemotactic, wound, healing, anticancer, cell, permeable, Tocris Bioscience, Miscellaneous Compound products

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