Cat. No. 5211

AM-TS23 C17H12N2O3S3 [1489285-17-7]

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Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone

Biological Activity

DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282. PMID: 24171552.

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Keywords: AM-TS23, supplier, DNA, polymerases, inhibitors, lambda, beta, cancer, sensitizers, AM-TS23, β, λ, inhibits, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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