TAK 21d

Cat. No. 5209

TAK 21d C19H17F2N7O [1143578-94-2]

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Chemical Name: 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide

Biological Activity

Potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

Technical Data

Soluble to 10 mM in DMSO and to 20 mM in 1eq. HCl
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468. PMID: 24440478.

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Keywords: TAK 21d, supplier, TAK21d, potent, inhibitors, inhibits, fatty, acid, amide, hydrolase, FAAH, neuropathic, inflammatory, pain, analgesic, Tocris Bioscience, Fatty Acid Amide Hydrolase Inhibitor products

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