JJKK 048

Cat. No. 5206

JJKK 048 C23H22N4O5 [1515855-97-6]

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Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone

Biological Activity

Potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6 respectively.

Technical Data

M.Wt:
434.44
Formula:
C23H22N4O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1515855-97-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Laitinen et al (2014) Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol.Pharmacol. 85 510. PMID: 24368842.

Aaltonen et al (2013) Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem.Biol. 20 379. PMID: 23521796.

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Citations are publications that use Tocris products.

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Keywords: JJKK 048, supplier, JJKK048, potent, selective, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, hydrolases, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products

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