TC-E 5007

Cat. No. 5204

TC-E 5007 C14H20N2O.HCl

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Alternative Name: allo-I1e-isoindoline

Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride

Biological Activity

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Technical Data

M.Wt:
268.78
Formula:
C14H20N2O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203. PMID: 19439267.

Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568. PMID: 17958345.

Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988. PMID: 16186403.

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Keywords: TC-E 5007, supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, Tocris Bioscience, Other Protease Inhibitor products

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