NIBR 189

Cat. No. 5203

NIBR 189 C21H21BrN2O3 [1599432-08-2]

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Chemical Name: (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one

Biological Activity

Potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Technical Data

M.Wt:
429.31
Formula:
C21H21BrN2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1599432-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Gessier et al (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J.Med.Chem. 57 3358. PMID: 24678947.

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Keywords: NIBR 189, supplier, NIBR189, potent, selective, EBI2, GPR183, Epstein-bar, virus, induced, gene, 2, receptors, antagonists, orally, bioavailable, Tocris Bioscience, Orphan 7-TM Receptor Antagonist products

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