Furamidine dihydrochloride

Cat. No. 5202

Furamidine dihydrochloride C18H16N4O.2HCl [55368-40-6]

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Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride

Biological Activity

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.

Technical Data

M.Wt:
377.27
Formula:
C18H16N4O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
55368-40-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yan et al (2014) Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 57 2611. PMID: 24564570.

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Citations are publications that use Tocris products.

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Keywords: Furamidine dihydrochloride, supplier, Selective, protein, arginine, methyltransferase, 1, PRMT1, inhibitors, inhibits, leukemia, coactivator-associated, arginine, methyltransferase, 1, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products

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