AZD 7762 hydrochloride

Cat. No. 5199

AZD 7762 hydrochloride C17H19FN4O2S.HCl [1246094-78-9]

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Chemical Name: 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride

Biological Activity

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Morgan et al (2010) Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 70 4972. PMID: 20501833.

Zabludoff et al (2008) AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 7 2955. PMID: 18790776.

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Keywords: AZD 7762 hydrochloride, supplier, AZD7762, hydrochloride, Potent, selective, ATP, competitive, inhibitors, inhibits, Chk1, Chk2, checkpoint, kinases, Tocris Bioscience, Checkpoint Kinase Inhibitor products

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