Cat. No. 5197
Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]
Biological ActivityInhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Salabei et al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375. PMID: 23421427.
Liu et al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223. PMID: 21962518.
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Keywords: Spautin 1, supplier, class, III, PI3, kinase, autophagy, inhibitors, inhibits, USP10, USP13, deubiquitinating, enzymes, vps34, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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