Spautin 1

Cat. No. 5197

Spautin 1 C15H11F2N3 [1262888-28-7]

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Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine

Biological Activity

Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Technical Data

M.Wt:
271.26
Formula:
C15H11F2N3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1262888-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Salabei et al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375. PMID: 23421427.

Liu et al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223. PMID: 21962518.

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Keywords: Spautin 1, supplier, class, III, PI3, kinase, autophagy, inhibitors, inhibits, USP10, USP13, deubiquitinating, enzymes, vps34, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

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