Agitoxin 2

Cat. No. 5195

Agitoxin 2 Gly-Val-Pro-Ile-Asn-Val-Ser-Cys-Thr-Gly-Ser-Pro-Gln-Cys-Ile-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys

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Biological Activity

Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).

Technical Data

M.Wt:
4090.87
Formula:
C169H278N54O48S8
Sequence:
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK

(Modifications: Disulfide bridge: 8-28,14-33,18-35)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
168147-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Anangi et al (2012) Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. PLoS ONE 7 e52965. PMID: 23300835.

Gross et al (1996) Agitoxin footprinting the shaker potassium channel pore. Neuron 16 399. PMID: 8789954 .

Garcia et al (1994) Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry 33 6834. PMID: 8204618.

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View Related Products by Product Action

Keywords: Agitoxin 2, supplier, potent, shaker, potassium, K+, channels, blockers, inhibits, inhibitors, Kv1.4, kv1.1, kv1.3, kv1.6, voltage, gated, venoms, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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