Cat. No. 5193

Remodelin  C15H14N4S [949912-58-7]

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Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile

Biological Activity

N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Larrieu et al (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344 527. PMID: 24786082.

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Keywords: Remodelin, supplier, NAT10, N-acetyltransferase, 10, aging, inhibitors, HGPS, Hutchinson-Gilford, progeria, syndrome, laminopathies, laminopathy, inhibits, Tocris Bioscience, Other Transferase Inhibitor products

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