NBI 31772

Cat. No. 5192

NBI 31772 C17H11NO7 [374620-70-9]

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Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid

Biological Activity

High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.

Technical Data

M.Wt:
341.27
Formula:
C17H11NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
374620-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Choi et al (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 140 660. PMID: 23293297.

Chen et al (2001) Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 44 4001. PMID: 11689087.

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Keywords: NBI 31772, supplier, NBI31772, High, affinity, insulin-like, growth, factor-1, binding, proteins, inhibitors, inhibits, IGFBP-3, IGF-1, cardiomyocytes, Tocris Bioscience, Insulin and Insulin-like Receptor products

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