Cat. No. 5192
Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydr
Biological ActivityHigh affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Choi et al (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 140 660. PMID: 23293297.
Chen et al (2001) Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 44 4001. PMID: 11689087.
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Keywords: NBI 31772, supplier, NBI31772, High, affinity, insulin-like, growth, factor-1, binding, proteins, inhibitors, inhibits, IGFBP-3, IGF-1, cardiomyocytes, Tocris Bioscience, Insulin and Insulin-like Receptors products
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