PTC 209

Cat. No. 5191

PTC 209 C17H13Br2N5OS [315704-66-6]

Price and Availability

For PTC 209 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Biological Activity

Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.

Technical Data

M.Wt:
495.19
Formula:
C17H13Br2N5OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
315704-66-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kreso et al (2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 20 29. PMID: 24292392.

If you know of a relevant reference for PTC 209 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses PTC 209 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: PTC 209, supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, 1, homolog, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Programmed Cell Death Life Science Poster

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

divider line

New Products in this Area

Pomalidomide

Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenic

Lenalidomide

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

cis VH 298

Negative control for VH 298

VH 298

High-affinity inhibitor of VHL

cis MZ 1

Negative Control for MZ1

MZ 1

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11