Cat. No. 5191
Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(
Biological ActivityBmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kreso et al (2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 20 29. PMID: 24292392.
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Keywords: PTC 209, supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, 1, homolog, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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