Cat. No. 5188
Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]
Biological ActivityInverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424. PMID: 22044162.
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Keywords: S 07662, supplier, S07662, inverse, agonists, constitutive, androstane, receptors, CAR, nuclear, Tocris Bioscience, Constitutive Androstane Receptor Antagonist products
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