S 07662

Cat. No. 5188

S 07662 C16H16N2O2S [883226-64-0]

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Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]-N'-(2-thienylmethyl)urea

Biological Activity

Inverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.

Technical Data

M.Wt:
300.38
Formula:
C16H16N2O2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
883226-64-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424. PMID: 22044162.

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Keywords: S 07662, supplier, S07662, inverse, agonists, constitutive, androstane, receptors, CAR, nuclear, Tocris Bioscience, Constitutive Androstane Receptor Antagonist products

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