Cat. No. 5188
Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]
Biological ActivityInverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424. PMID: 22044162.
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Keywords: S 07662, supplier, S07662, inverse, agonists, constitutive, androstane, receptors, CAR, nuclear, Tocris Bioscience, Constitutive Androstane Receptor Antagonist products