JTE 607 dihydrochloride
Cat. No. 5185
Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-m
Biological ActivityCytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tajima et al (2010) JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 101 774. PMID: 20028380.
Jian (2004) JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol. 488 231. PMID: 15044056.
Kakutani et al (1999) JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res. 48 461. PMID: 10493164.
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Keywords: JTE 607 dihydrochloride, supplier, JTE607, dihydrochloride, cytokines, inhibitors, inhibits, TNFa, TNF-alpha, TNF-α, interleukins, IL-1beta, IL-1b, IL-1β, inflammation, anti-inflammatory, IL-6, IL-8, IL-10, apoptosis, Tocris Bioscience, Cytokine products
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