ETP 45835 dihydrochloride

Cat. No. 5183

ETP 45835 dihydrochloride C13H16N4.2HCl

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Chemical Name: 4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride

Biological Activity

Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data

M.Wt:
301.21
Formula:
C13H16N4.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618. PMID: 20722422.

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Citations are publications that use Tocris products.

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Keywords: ETP 45835 dihydrochloride, supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Tocris Bioscience, Mnk Inhibitor products

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